| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenBcm1 Surface AntigenBlast-1Hm48-1Mrc Ox-45 Surface AntigenSlam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Sgp-60Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Protein Names | Cd48 Antigen proteinBcm1 Surface Antigen proteinBlast-1 proteinHm48-1 proteinMrc Ox-45 Surface Antigen proteinSlam Family Member 2 proteinSlamf2 proteinSignaling Lymphocytic Activation Molecule 2 proteinSgp-60 proteinCd Antigen Cd48 proteinCd48 proteinBcm-1 protein |
Information sourced from Uniprot.org
