| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CCR1 Blocking Peptide for STJ500396 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CCR1 |
| Gene ID: |
1230 |
| Uniprot ID: |
CCR1_HUMAN |
| Immunogen Region: |
1-50 |
| Specificity: |
This blocking peptide is recommended for use in combination with CCR1 antibody, STJ500396 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-50 on human CCR1 protein. |
| Tissue Specificity | Widely expressed in different hematopoietic cells. |
| Function | Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Mediates also monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway. |
| Peptide Name | C-C Chemokine Receptor Type 1C-C Ckr-1Cc-Ckr-1Ccr-1Ccr1Hm145Ld78 ReceptorMacrophage Inflammatory Protein 1-Alpha ReceptorMip-1alpha-RRantes-RCd Antigen Cd191 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | C-C Chemokine Receptor Type 1 proteinC-C Ckr-1 proteinCc-Ckr-1 proteinCcr-1 proteinCcr1 proteinHm145 proteinLd78 Receptor proteinMacrophage Inflammatory Protein 1-Alpha Receptor proteinMip-1alpha-R proteinRantes-R proteinCd Antigen Cd191 proteinCCR1 proteinCMKBR1 proteinCMKR1 proteinSCYAR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
