| Post Translational Modifications | Phosphorylation of Ser-402 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Peptide Name | Brca1-A Complex Subunit Abraxas 1Coiled-Coil Domain-Containing Protein 98Protein Fam175a |
| Database Links | Reactome: R-RNO-5689901Reactome: -RNO-5693565Reactome: -RNO-5693571Reactome: -RNO-5693607Reactome: -RNO-69473 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Peptide Names | Brca1-A Complex Subunit Abraxas 1 proteinCoiled-Coil Domain-Containing Protein 98 proteinProtein Fam175a proteinABRAXAS1 proteinAbra1 proteinCcdc98 proteinFam175a protein |
Information sourced from Uniprot.org
