CCDC98 Blocking Peptide for STJ500022 peptide (STJ503617)
General Information
| Short Description | CCDC98 Blocking Peptide for STJ500022 is synthetically produced from the 350-400 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ABRAXAS1 |
| Gene ID | 84142 |
| Uniprot ID | ABRX1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein. |
| Immunogen Region | 350-400 |
| Specificity | This blocking peptide is recommended for use in combination with CCDC98 antibody, STJ500022 |
Additional Info
| Post Translational Modifications | Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage. |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Peptide Name | Brca1-A Complex Subunit Abraxas 1Coiled-Coil Domain-Containing Protein 98Protein Fam175a |
| Database Links | Reactome: R-HSA-5689901Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-69473 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Peptide Names | Brca1-A Complex Subunit Abraxas 1 proteinCoiled-Coil Domain-Containing Protein 98 proteinProtein Fam175a proteinABRAXAS1 proteinABRA1 proteinCCDC98 proteinFAM175A proteinUNQ496 proteinPRO1013 protein |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about CCDC98 Blocking Peptide for STJ500022 peptide (STJ503617)
This is a blocking peptide intended for use in immunodepletion and immunocompetition experiments in combination with the CCDC98 antibody STJ500022. It is not an antibody itself and should not be used as a standalone detection reagent.
This blocking peptide is a synthetic peptide derived from amino acid region 350 to 400 of the human BRCA1-A complex subunit Abraxas protein, corresponding to UniProt entry Q6UWZ7.
This peptide is supplied in liquid form at 2.5 mg/ml in PBS, with up to 5% DMSO optionally added. Orders exceeding 1 mg can be supplied in lyophilized powder form or reformulated in a buffer of choice upon request.
This product is recommended for immunodepletion and immunocompetition applications, where it is used alongside the paired CCDC98 antibody STJ500022 to confirm antibody specificity.
This peptide should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain stability.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.