| Host: |
CHO cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Cardiac Troponin complex-protein was developed from cho cells. For use in research applications. |
| Formulation: |
25 mM Tris, pH 7.5, 500 mM NaCl5 mM CaCl2, 15 mM Beta-mercaptoethanol |
| Purification: |
Antibody-affinity purification following desalting |
| Concentration: |
1 mg/ml |
| Storage Instruction: |
Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Post Translational Modifications | Phosphorylated at Ser-42 and Ser-44 by PRKCE.phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1.phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). |
| Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin I - Cardiac MuscleCardiac Troponin I |
| Database Links | Reactome: R-HSA-390522Reactome: R-HSA-5578775 |
| Alternative Protein Names | Troponin I - Cardiac Muscle proteinCardiac Troponin I proteinTNNI3 proteinTNNC1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
