Cardiac Troponin complex protein (STJP000154)

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STJP000154
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Host: CHO cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Cardiac Troponin complex-protein was developed from cho cells. For use in research applications.
Formulation: 25 mM Tris, pH 7.5, 500 mM NaCl5 mM CaCl2, 15 mM Beta-mercaptoethanol
Purification: Antibody-affinity purification following desalting
Concentration: 1 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: TNNI3
Gene ID: 7137
Uniprot ID: TNNI3_HUMAN
Post Translational Modifications Phosphorylated at Ser-42 and Ser-44 by PRKCE.phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1.phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Protein Name Troponin I - Cardiac Muscle
Cardiac Troponin I
Database Links Reactome: R-HSA-390522
Reactome: R-HSA-5578775
Alternative Protein Names Troponin I - Cardiac Muscle protein
Cardiac Troponin I protein
TNNI3 protein
TNNC1 protein

Information sourced from Uniprot.org

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