CACNB2 Positive Control for STJ502190 peptide (STJ503817)

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STJ503817-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : CACNB2 Positive Control for STJ502190 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Cacnb2
Gene ID: 116600
Uniprot ID: CACB2_RAT
Specificity: This is positive control is recommended for use in combination with CACNB2 antibody STJ502190.
Tissue Specificity Highly expressed in heart and brain, and at lower levels in lung.
Post Translational Modifications Regulated through phosphorylation at Thr-549 by CaMK2D.
Function Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.
Peptide Name Voltage-Dependent L-Type Calcium Channel Subunit Beta-2
Cab2
Calcium Channel Voltage-Dependent Subunit Beta 2
Database Links Reactome: R-RNO-112308
Reactome: -RNO-422356
Reactome: -RNO-5576892
Reactome: -RNO-5576893
Cellular Localisation Cell Membrane
Sarcolemma
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Peptide Names Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 protein
Cab2 protein
Calcium Channel Voltage-Dependent Subunit Beta 2 protein
Cacnb2 protein
Cacnlb2 protein

Information sourced from Uniprot.org

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