| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
BMPR1A Blocking Peptide for STJ500281 is synthetically produced from the 460-510 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Dilution Range: |
WB: IHC: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
BMPR1A |
| Gene ID: |
657 |
| Uniprot ID: |
BMR1A_HUMAN |
| Immunogen Region: |
460-510 |
| Specificity: |
This blocking peptide is recommended for use in combination with BMPR1A antibody, STJ500281 |
| Immunogen: |
Synthetic peptide taken within amino acid region 460-510 on human Bone morphogenetic protein receptor type-1A. |
| Tissue Specificity | Highly expressed in skeletal muscle. |
| Post Translational Modifications | Glycosylated. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. |
| Peptide Name | Bone Morphogenetic Protein Receptor Type-1aBmp Type-1a ReceptorBmpr-1aActivin Receptor-Like Kinase 3Alk-3Serine/Threonine-Protein Kinase Receptor R5Skr5Cd Antigen Cd292 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Peptide Names | Bone Morphogenetic Protein Receptor Type-1a proteinBmp Type-1a Receptor proteinBmpr-1a proteinActivin Receptor-Like Kinase 3 proteinAlk-3 proteinSerine/Threonine-Protein Kinase Receptor R5 proteinSkr5 proteinCd Antigen Cd292 proteinBMPR1A proteinACVRLK3 proteinALK3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
