Trial size DLG4 antibodies available in the Antibody Validation Project

Introduction:

Discs large MAGUK scaffold protein 4 is the protein encoded by the DLG4 gene and takes part in the NMDA receptors and combined with another protein from the same family can interact at postsynaptic sites. The DLG4 protein can primairly be found in the brain and some cells of the immune system, but disorders of its expression or mutations can cause degeneration of the brain, several mental disorders and Huntington's disease. We provide a number of trial sized antibodies, which are suitable for DLG4 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding DDIT3 that we have provided in the links below.

• What is DLG4?
• Where is DLG4 found?
• What role does DLG4 play in disease?
• DLG4 antibodies in the Antibody Validation project
• Customer reviewed DLG4 antibodies
• Other DLG4 antibodies available in the Antibody Validation Project
• Popular DLG4 antibodies not currently in the Antibody Validation Project
• How does the Antibody Validation Project work?

What is DLG4?

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family.The potein which is sythesised heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

Where is DLG4 found?

This protein is expressed mainly in the brain tissue and several immune cells, including plasmacytoid DC and memory CD8 T-cell. Inside the cell, it is localised in the plasma membrane and cytoskeleton in higher quantities.

What role does DLG4 play in disease?

DLG4 is an important gene for cerebral degeneration. Apart from that, mutations of this gene can cause Huntington's disease, Schizophrenia and Autism Spectrum disorder. Furthermore, overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons.

DLG4 antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target DLG4 , which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed DLG4 antibodies

Model	Name	Host	Clonality	Rating	Application Tested
STJ95244	Anti-PSD-95 antibody	Rabbit	Polyclonal	4	ICC

Other DLG4 antibodies available in the Antibody Validation Project

Currently we do not have any other DLG4 antibodies available in the AVP.

Popular DLG4 antibodies not currently in the Antibody Validation Project

Model	Name	Host	Clonality	Recommended Applications
STJ110199	Anti-DLG4 Antibody	Rabbit	Polyclonal	WB
STJ112737	Anti-DLG4 Antibody	Rabbit	Monoclonal	WB,IHC,IF,IP
STJ27954	Anti-DLG4 Antibody	Rabbit	Polyclonal	WB,IHC,IP

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.