Trial size DIO3 antibodies available in the Antibody Validation Project

Introduction:

Iodothyronine deiodinase 3 is the protein synthesised by the DIO3 gene. This enzyme catalyzes the inactivation of thyroid hormone and also plays an important role in infant mammalian development. This selenoprotein can be found highly expressed in placenta, pregnant uterus, basal ganglia and fetal tissues, but overexpression or mutations of DIO3 can lead to Praeder-Willi, Allan-Herndon-Dudley syndromes and other disorders of the endocrine system. We provide a number of trial sized antibodies, which are suitable for DIO3 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding DIO3 that we have provided in the links below.

• What is DIO3?
• Where is DIO3 found?
• What role does DIO3 play in disease?
• DIO3 antibodies in the Antibody Validation project
• Customer reviewed DIO3 antibodies
• Other DIO3 antibodies available in the Antibody Validation Project
• Popular DIO3 antibodies not currently in the Antibody Validation Project
• How does the Antibody Validation Project work?

What is DIO3?

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family and catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Furthermore, it regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development.The DIO3 protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Where is DIO3 found?

The enzyme encoded by the DIO3 gene is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. 

What role does DIO3 play in disease?

Serving such a rare and important role in the human body, any disorders in the expression or mutations can lead to serious conditions. Increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism and furthermore, several brain and muscle development disorders visible during infancy can occur if DIO3 is not expressed properly.

DIO3 antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target DIO3 , which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed DIO3 antibodies

Model	Name	Host	Clonality	Rating	Application Tested
STJ92717	Anti-DIO3 antibody	Rabbit	Polyclonal	5	WB

Other DIO3 antibodies available in the Antibody Validation Project

Currently we do not have any other DIO3 antibodies available in the AVP.

Popular DIO3 antibodies not currently in the Antibody Validation Project

Model	Name		Host		Clonality	Recommended Applications
STJ28980	Anti-DIO3 Antibody		Rabbit		Polyclonal	WB

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.