Posted by M.Popov on 12th Nov 2020
Trial size CD74 antibodies available in the Antibody Validation Project
Trial size CD74 antibodies available in the Antibody Validation Project
Introduction:
CD74 is a gene synthesising the CD74 molecule, a protein responsible for MHC class II antigen processing and serving as a cell surface receptor for MIF. Apart from its normal function, mutations of this gene can lead to several types of cancer and immune diseases. We provide a number of trial sized antibodies, which are suitable for CD74 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding CD74 that we have provided in the links below.
- What is CD74?
- Where is CD74 found?
- What role does CD74 play in disease?
- CD74 antibodies in the Antibody Validation project
- Customer reviewed CD74 antibodies
- Other CD74 antibodies available in the Antibody Validation Project
- Popular CD74 antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is CD74?
The protein, named CD74 molecule, encoded by this gene plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta.
Where is CD74 found?
CD74 can mainly be found inside the Golgi apparatus and has cytoplasmic and membranous expression in macrophages and immune cells in several tissues.
What role does CD74 play in disease?
A chromosomal aberration involving CD74 is found in a non-small cell lung tumor and results in the formation of a CD74-ROS1 chimeric protein. Furthermore, overexpression or other mutations cal lead to undifferentiated pleomorphic sarcoma.
CD74 antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target CD74, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed CD74 antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ96829 | Anti-CD74 antibody | Rabbit | Polyclonal | 4 | WB |
Other CD74 antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ190022 | Anti-CD74 antibody | Mouse | Monoclonal | IHC-p |
Popular CD74 antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ115893 | Anti-CD74 Antibody | Rabbit | Polyclonal | WB |
| STJ160033 | Anti-CD74 antibody | Mouse | Monoclonal | IHC |
| STJ27634 | Anti-CD74 Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ73084 | Anti-CD74 Antibody | Goat | Polyclonal | ELISA,WB |
| STJ73085 | Anti-CD74 Antibody | Goat | Polyclonal | ELISA,WB |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.