Trial size ATP6V0D1 antibodies available in the Antibody Validation Project

Introduction:

The ATPase H+ transporting V0 subunit d1 is a protein synthesised by the ATP6V0D1 gene and is responsible for many intracellular processes, such as protein sorting and synaptic vesicle proton gradient generation. Because of its role in cancer, it can be used as a prognostic marker for favourable renal and pancreatic cancer. We provide a number of trial sized antibodies, which are suitable for ATP6V0D1 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding ATP6V0D1 that we have provided in the links below.

• What is ATP6V0D1?
• Where is ATP6V0D1 found?
• What role does ATP6V0D1 play in disease?
• ATP6V0D1 antibodies in the Antibody Validation project
• Customer reviewed ATP6V0D1 antibodies
• Other ATP6V0D1 antibodies available in the Antibody Validation Project
• Popular ATP6V0D1 antibodies not currently in the Antibody Validation Project
• How does the Antibody Validation Project work?

What is ATP6V0D1?

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. 

Where is ATP6V0D1 found?

The ATP6V0D1 protein can be found in the cytoplasm at intracellular level, and has expression at varying levels in several tissues.

What role does ATP6V0D1 play in disease?

Mutations of the ATP6V0D1 gene are associated with both eye and congenital abnormalities. Several mutations have been found in low tissue specific human cancers.

ATP6V0D1 antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target ATP6V0D1, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed ATP6V0D1 antibodies

Model	Name	Host	Clonality	Rating	Application Tested
STJ96391	Anti-V-ATPase D1 antibody	Rabbit	Polyclonal	4	WB

Other ATP6V0D1 antibodies available in the Antibody Validation Project

Currently we do not have any ATP6V0D1 antibodies available in the AVP.

Popular ATP6V0D1 antibodies not currently in the Antibody Validation Project

Model	Name		Host		Clonality	Recommended Applications
STJ22726	Anti-ATP6V0D1 Antibody		Rabbit		Polyclonal	WB

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.