| Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. |
| Protein Name | Frizzled-8Fz-8Hfz8 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-4608870Reactome: R-HSA-4641263Reactome: R-HSA-5340588 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinGolgi ApparatusCell MembraneColocalizes With Gopc At The Golgi Apparatus |
| Alternative Protein Names | Frizzled-8 proteinFz-8 proteinHfz8 proteinFZD8 protein |
Information sourced from Uniprot.org
