Atypical Chemokine Receptor D6 Blocking Peptide peptide (STJ503622)
General Information
| Short Description | Atypical Chemokine Receptor D6 Blocking Peptide is synthetically produced from the 200-300 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ACKR2 |
| Gene ID | 1238 |
| Uniprot ID | ACKR2_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 200-300 on ACRD6 protein. |
| Immunogen Region | 200-300 |
Additional Info
| Tissue Specificity | Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. |
| Post Translational Modifications | Phosphorylated on serine residues in the C-terminal cytoplasmic tail. |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. |
| Peptide Name | Atypical Chemokine Receptor 2C-C Chemokine Receptor D6Chemokine Receptor Ccr-10Chemokine Receptor Ccr-9Chemokine-Binding Protein 2Chemokine-Binding Protein D6 |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Early EndosomeRecycling EndosomeCell MembraneMulti-Pass Membrane ProteinPredominantly Localizes To Endocytic VesiclesAnd Upon Stimulation By The Ligand Is Internalized Via Clathrin-Coated PitsOnce InternalizedThe Ligand Dissociates From The ReceptorAnd Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane |
| Alternative Peptide Names | Atypical Chemokine Receptor 2 proteinC-C Chemokine Receptor D6 proteinChemokine Receptor Ccr-10 proteinChemokine Receptor Ccr-9 proteinChemokine-Binding Protein 2 proteinChemokine-Binding Protein D6 proteinACKR2 proteinCCBP2 proteinCCR10 proteinCMKBR9 proteinD6 protein |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Atypical Chemokine Receptor D6 Blocking Peptide peptide (STJ503622)
This is a synthetic blocking peptide corresponding to a region of the Atypical Chemokine Receptor D6 (ACRD6) protein, UniProt O00590. It is designed for use in immunodepletion and immunocompetition experiments, typically to confirm antibody specificity by competing with the target antigen for antibody binding.
The peptide is derived from a synthetic sequence taken within amino acid region 200 to 300 of the ACRD6 protein (UniProt O00590).
This peptide is recommended for immunodepletion and immunocompetition applications. It is intended for research use only and is not suitable for diagnostic or therapeutic purposes.
This peptide is supplied in liquid form at a concentration of 2.5 mg/ml in PBS, with up to 5% DMSO optionally added. Orders greater than 1 mg can be supplied in lyophilized powder form or in a buffer of the customer's choice.
This peptide should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.