ASXL3 Blocking Peptide peptide (STJ505772)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 350-410 on human Tyrosine-protein kinase ZAP-70.
General Information
| Short Description | ASXL3 Blocking Peptide is synthetically produced from the 350-410 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Asxl3 |
| Gene ID | 211961 |
| Uniprot ID | ASXL3_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 350-410 on human Tyrosine-protein kinase ZAP-70. |
| Immunogen Region | 350-410 |
Additional Info
| Function | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes. |
| Peptide Name | Putative Polycomb Group Protein Asxl3Additional Sex Combs-Like Protein 3 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Putative Polycomb Group Protein Asxl3 proteinAdditional Sex Combs-Like Protein 3 proteinAsxl3 protein |
Information sourced from Uniprot.org