| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Phospho-Aquaporin 2 Blocking Peptide is synthetically produced from the 200-240 sequence and is suitable for use in western blot applications. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Aqp2 |
| Gene ID: |
25386 |
| Uniprot ID: |
AQP2_RAT |
| Immunogen Region: |
200-240 |
| Immunogen: |
Synthetic peptide taken within amino acid region 200-240 on rat Aquaporin 2 protein. Phosphorylated Serine 218 residue. |
| Tissue Specificity | Detected in kidney, in cortical and the medullary collecting tubules (at protein level). Detected in kidney medulla and cortex. |
| Post Translational Modifications | Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. N-glycosylated. |
| Function | Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. |
| Peptide Name | Aquaporin-2Aqp-2Adh Water ChannelAquaporin-CdAqp-CdCollecting Duct Water Channel ProteinWch-CdWater Channel Protein For Renal Collecting Duct |
| Database Links | Reactome: R-RNO-432040Reactome: -RNO-432047 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCell MembraneCytoplasmic Vesicle MembraneGolgi ApparatusTrans-Golgi Network MembraneShuttles From Vesicles To The Apical MembraneVasopressin-Regulated Phosphorylation Is Required For Translocation To The Apical Cell MembranePlekha8/Fapp2 Is Required To Transport Aqp2 From The Tgn To Sites Where Aqp2 Is Phosphorylated |
| Alternative Peptide Names | Aquaporin-2 proteinAqp-2 proteinAdh Water Channel proteinAquaporin-Cd proteinAqp-Cd proteinCollecting Duct Water Channel Protein proteinWch-Cd proteinWater Channel Protein For Renal Collecting Duct proteinAqp2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
