| Tissue Specificity | Widely expressed. |
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER).the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER. |
| Protein Name | Centromere/Kinetochore Protein Zw10 Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-6811434Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembranePeripheral Membrane ProteinChromosomeCentromereKinetochoreCytoskeletonSpindleLipid DropletDynamic Pattern Of Localization During The Cell CycleIn Most Cells At InterphasePresent Diffusely In The CytoplasmIn PrometaphaseAssociated With The KinetochoreAt MetaphaseDetected Both At The Kinetochores AndMost ProminentlyAt The SpindleParticularly At The Spindle PolesIn Very Early AnaphaseDetected On Segregating KinetochoresIn Late Anaphase And TelophaseAccumulates At The Spindle Midzone |
| Alternative Antibody Names | Anti-Centromere/Kinetochore Protein Zw10 Homolog antibodyAnti-ZW10 antibody |
Information sourced from Uniprot.org
