Anti-ZW10 antibody (1-220 aa) (STJ11106620)

SKU:
STJ11106620

£112.50 - £524.50
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: ZW10
Gene ID: 9183
Uniprot ID: ZW10_HUMAN
Immunogen Region: 1-220 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZW10 (NP_004715.1).
Immunogen Sequence: MASFVTEVLAHSGRLEKEDL GTRISRLTRRVEEIKGEVCN MISKKYSEFLPSMQSAQGLI TQVDKLSEDIDLLKSRIESE VRRDLHVSTGEFTDLKQQLE RDSVVLSLLKQLQEFSTAIE EYNCALTEKKYVTGAQRLEE AQKCLKLLKSRKCFDLKILK SLSMELTIQKQNILYHLGEE WQKLIVWKFPPSKDTSSLES YLQTELHLYTEQSHKEEKTP
Tissue Specificity Widely expressed.
Function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER).the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER.
Protein Name Centromere/Kinetochore Protein Zw10 Homolog
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-6811434
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Chromosome
Centromere
Kinetochore
Cytoskeleton
Spindle
Lipid Droplet
Dynamic Pattern Of Localization During The Cell Cycle
In Most Cells At Interphase
Present Diffusely In The Cytoplasm
In Prometaphase
Associated With The Kinetochore
At Metaphase
Detected Both At The Kinetochores And
Most Prominently
At The Spindle
Particularly At The Spindle Poles
In Very Early Anaphase
Detected On Segregating Kinetochores
In Late Anaphase And Telophase
Accumulates At The Spindle Midzone
Alternative Antibody Names Anti-Centromere/Kinetochore Protein Zw10 Homolog antibody
Anti-ZW10 antibody

Information sourced from Uniprot.org

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