| Function | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation. Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target. May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation. Plays an essential role for proper embryonic development of heart and lung. Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated. |
| Protein Name | Zinc Finger Swim Domain-Containing Protein 8 |
| Cellular Localisation | CytoplasmCytosolTranslocates Together With Its Substrate Into Stress Granules (Sgs) Under Proteostatic Stress |
| Alternative Antibody Names | Anti-Zinc Finger Swim Domain-Containing Protein 8 antibodyAnti-Zswim8 antibodyAnti-Kiaa0913 antibody |
Information sourced from Uniprot.org
