| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ubiquitin thioesterase ZRANB1 (255-305 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZRANB1 |
| Gene ID: |
54764 |
| Uniprot ID: |
ZRAN1_HUMAN |
| Immunogen Region: |
255-305 aa |
| Specificity: |
This antibody detects endogenous levels of ZRAN1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human ZRAN1 at the amino acid range 255-305 |
| Function | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. |
| Protein Name | Ubiquitin Thioesterase Zranb1Traf-Binding Domain-Containing ProteinHtrabidZinc Finger Ran-Binding Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusEnriched In Punctate Localization In The Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin Thioesterase Zranb1 antibodyAnti-Traf-Binding Domain-Containing Protein antibodyAnti-Htrabid antibodyAnti-Zinc Finger Ran-Binding Domain-Containing Protein 1 antibodyAnti-ZRANB1 antibodyAnti-TRABID antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
