| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZPR1 (110-459) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZPR1 |
| Gene ID: |
8882 |
| Uniprot ID: |
ZPR1_HUMAN |
| Immunogen Region: |
110-459 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 110-459 of human ZPR1 (NP_003895.1). |
| Immunogen Sequence: |
LEDMNREVVKTDSAATRIPE LDFEIPAFSQKGALTTVEGL ITRAISGLEQDQPARRANKD ATAERIDEFIVKLKELKQVA SPFTLIIDDPSGNSFVENPH APQKDDALVITHYNRTRQQE EMLGLQEEAPAEKPEEEDLR NEVLQFSTNCPECNAPAQTN MKLVQIPHFKEVIIMATNCE NCGHRTNEVKSGGAVEPLGT RITLHITDASDMTRDLLKSE TCSVEIPELEFELGMAVLG |
| Tissue Specificity | Expressed in fibroblast.weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients. |
| Function | Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. |
| Protein Name | Zinc Finger Protein Zpr1Zinc Finger Protein 259 |
| Cellular Localisation | NucleusNucleolusGemCajal BodyCytoplasmPerinuclear RegionCell ProjectionAxonGrowth ConeColocalized With Smn1 In Gemini Of Coiled Bodies (Gems)Cajal BodiesAxon And Growth Cones Of NeuronsLocalized Predominantly In The Cytoplasm In Serum-Starved Cells Growth Arrested In G0 Of The Mitotic Cell CycleLocalized Both In The Nucleus And Cytoplasm At The G1 Phase Of The Mitotic Cell CycleAccumulates In The Subnuclear Bodies During Progression Into The S Phase Of The Mitotic Cell CycleDiffusely Localized Throughout The Cell During MitosisColocalized With Npat And Smn1 In Nuclear Bodies Including Gems (Gemini Of Coiled Bodies) And Cajal Bodies In A Cell Cycle-Dependent MannerTranslocates Together With Eef1a1 From The Cytoplasm To The Nucleolus After Treatment With MitogensColocalized With Egfr In The Cytoplasm Of Quiescent CellsTranslocates From The Cytoplasm To The Nucleus In A Epidermal Growth Factor (Egf)-Dependent Manner |
| Alternative Antibody Names | Anti-Zinc Finger Protein Zpr1 antibodyAnti-Zinc Finger Protein 259 antibodyAnti-ZPR1 antibodyAnti-ZNF259 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
