| Short Description : | Rabbit polyclonal ZP1 (340-610) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZP1 |
| Gene ID: | 22917 |
| Uniprot ID: | ZP1_HUMAN |
| Immunogen Region: | 340-610 |
| Immunogen Sequence: | AGDQLIYENWLVSGIHIQKG PQGSITRDSTFQLHVRCVFN ASDFLPIQASIFPPPSPAPM TQPGPLRLELRIAKDETFSS YYGEDDYPIVRLLREPVHVE VRLLQRTDPNLVLLLHQCWG APSANPFQQPQWPILSDGCP FKGDSYRTQMVALDGATPFQ SHYQRFTVATFALLDSGSQR ALRGLVYLFCSTSACHTSGL ETCSTACSTGTTRQRRSSGH RNDTARPQDIVSSPGPVGF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human ZP1 (NP_997224.2). |
| Tissue Specificity | Expressed in oocytes (at protein level). |
| Post Translational Modifications | Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. O-glycosylated. |
| Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. |
| Protein Name | Zona Pellucida Sperm-Binding Protein 1Zona Pellucida Glycoprotein 1Zp-1 Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 1 |
| Database Links | Reactome: R-HSA-2534343 |
| Cellular Localisation | Processed Zona Pellucida Sperm-Binding Protein 1: Zona PellucidaCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Zona Pellucida Sperm-Binding Protein 1 antibodyAnti-Zona Pellucida Glycoprotein 1 antibodyAnti-Zp-1 Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 1 antibodyAnti-ZP1 antibody |
Information sourced from Uniprot.org
