| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZNRF3 |
| Gene ID: | 84133 |
| Uniprot ID: | ZNRF3_HUMAN |
| Immunogen Region: | 108-119 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ZNRF3 (NP_001193927.1). |
| Immunogen Sequence: | QMHPLGLCNNNDEEDLYEYG WVGVVKLEQPELDPKPCLTV LGKAKRAVQRGATAVIFDVS ENPEAIDQLNQGSEDPLKRP VVYVKGADAIKLMNIVNKQK VARARIQHRPPRQPTEYFDM GIFLAFFVVVSLVCLILLVK IKLKQRRSQNSMNRLAVQAL EKMETRKFNSKSKGRREGSC GALDTLSSSSTSDCAICLEK |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification. |
| Protein Name | E3 Ubiquitin-Protein Ligase Znrf3Ring Finger Protein 203Ring-Type E3 Ubiquitin Transferase Znrf3Zinc/Ring Finger Protein 3 |
| Database Links | Reactome: R-HSA-4641263 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Znrf3 antibodyAnti-Ring Finger Protein 203 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Znrf3 antibodyAnti-Zinc/Ring Finger Protein 3 antibodyAnti-ZNRF3 antibodyAnti-KIAA1133 antibodyAnti-RNF203 antibody |
Information sourced from Uniprot.org