| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZNF451 (600-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF451 |
| Gene ID: |
26036 |
| Uniprot ID: |
ZN451_HUMAN |
| Immunogen Region: |
600-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ZNF451 (NP_001026794.1). |
| Immunogen Sequence: |
SSPRGKWQCRICEDMFDSQE YVKQHCMSLASHKFHRYSCA HCRKPFHKIETLYRHCQDEH DNEIKIKYFCGLCDLIFNVE EAFLSHYEEHHSIDYVFVSE KTETSIKTEDDFPVIETSNQ LTCGCRESYICKVNRKEDYS RCLQIMLDKGKLWFRCSLCS ATAQNLTDMNTHIHQVHKEK SDEEEQQYVIKCGTCTKAFH DPESAQQHFHRKHCFLQKPS VAHFGSEKSNLYKFTASAS |
| Post Translational Modifications | Sumoylated. Predominantly sumoylated on the N-terminal region that is important for interaction with SUMO1 and SUMO2. Sumoylation is important for localization in nuclear granules.desumoylation leads to diffuse nucleoplasmic location. Autosumoylated (in vitro). Sumoylation enhances E3 SUMO-protein ligase activity. |
| Function | E3 SUMO-protein ligase.has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets. |
| Protein Name | E3 Sumo-Protein Ligase Znf451Coactivator For Steroid ReceptorsE3 Sumo-Protein Transferase Znf451Zinc Finger Protein 451 |
| Cellular Localisation | NucleusPml BodyNucleoplasmColocalizes With Ube2i/Ubc9Sumo1 And Sumo2 In Nuclear GranulesThis Probably Requires SumoylationDesumoylation Leads To Diffuse Nucleoplasmic Location |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Znf451 antibodyAnti-Coactivator For Steroid Receptors antibodyAnti-E3 Sumo-Protein Transferase Znf451 antibodyAnti-Zinc Finger Protein 451 antibodyAnti-ZNF451 antibodyAnti-COASTER antibodyAnti-KIAA0576 antibodyAnti-KIAA1702 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
