| Tissue Specificity | Expressed in all tissues tested, with the strongest expression in ovary. |
| Function | Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32. |
| Protein Name | Zinc Finger Protein 143Sph-Binding FactorSelenocysteine Trna Gene Transcription-Activating FactorHstaf |
| Database Links | Reactome: R-HSA-6807505Reactome: R-HSA-749476Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 143 antibodyAnti-Sph-Binding Factor antibodyAnti-Selenocysteine Trna Gene Transcription-Activating Factor antibodyAnti-Hstaf antibodyAnti-ZNF143 antibodyAnti-SBF antibodyAnti-STAF antibody |
Information sourced from Uniprot.org
