Anti-ZMYND11 antibody (278-567) (STJ28249)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZMYND11 (278-567) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZMYND11 |
| Gene ID | 10771 |
| Uniprot ID | ZMY11_HUMAN |
| Immunogen Region | 278-567 |
| Immunogen Sequence | PNHELVWAKMKGFGFWPAKV MQKEDNQVDVRFFGHHHQRA WIPSENIQDITVNIHRLHVK RSMGWKKACDELELHQRFLR EGRFWKSKNEDRGEEEAESS ISSTSNEQLKVTQEPRAKKG RRNQSVEPKKEEPEPETEAV SSSQEIPTMPQPIEKVSVST QTKKLSASSPRMLHRSTQTT NDGVCQSMCHDKYTKIFNDF KDRMKSDHKRETERVVREAL EKLRSEMEEEKRQAVNKAV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 278-567 of human ZMYND11 (NP_997644.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylated following its interaction with PIAS1 and UBE2I. Ubiquitinated, leading to proteasomal degradation. |
| Function | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. |
| Protein Name | Zinc Finger Mynd Domain-Containing Protein 11Adenovirus 5 E1a-Binding ProteinBone Morphogenetic Protein Receptor-Associated Molecule 1Protein Bs69 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin And Mitotic Chromosomes |
| Alternative Antibody Names | Anti-Zinc Finger Mynd Domain-Containing Protein 11 antibodyAnti-Adenovirus 5 E1a-Binding Protein antibodyAnti-Bone Morphogenetic Protein Receptor-Associated Molecule 1 antibodyAnti-Protein Bs69 antibodyAnti-ZMYND11 antibodyAnti-BRAM1 antibodyAnti-BS69 antibody |
Information sourced from Uniprot.org