Anti-ZIC1 antibody (1-100) [S8MR] (STJ11103038)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ZIC1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S8MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZIC1 |
| Gene ID | 7545 |
| Uniprot ID | ZIC1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MLLDAGPQYPAIGVTTFGAS RHHSAGDVAERDVGLGINPF ADGMGAFKLNPSSHELASAG QTAFTSQAPGYAAAAALGHH HHPGHVGSYSSAAFNSTRDF |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ZIC1 (Q15915). |
Additional Info
| Tissue Specificity | CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. |
| Function | Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. |
| Protein Name | Zinc Finger Protein Zic 1Zinc Finger Protein 201Zinc Finger Protein Of The Cerebellum 1 |
| Database Links | Reactome: R-HSA-9834899Reactome: R-HSA-9856649 |
| Cellular Localisation | NucleusCytoplasmLocalizes In The Cytoplasm In Presence Of Mdfic Overexpression |
| Alternative Antibody Names | Anti-Zinc Finger Protein Zic 1 antibodyAnti-Zinc Finger Protein 201 antibodyAnti-Zinc Finger Protein Of The Cerebellum 1 antibodyAnti-ZIC1 antibodyAnti-ZIC antibodyAnti-ZNF201 antibody |
Information sourced from Uniprot.org