| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZGPAT (213-272) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZGPAT |
| Gene ID: |
84619 |
| Uniprot ID: |
ZGPAT_HUMAN |
| Immunogen Region: |
213-272 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 213-272 of human ZGPAT (NP_115916.3). |
| Immunogen Sequence: |
PDLSSLQAGSACLAKHQDGL WHAARITDVDNGYYTVKFDS LLLREAVVEGDGILPPLRTE |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP. |
| Function | Transcription repressor that specifically binds the 5'-GGAGGAAGAA-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. |
| Protein Name | Zinc Finger Ccch-Type With G Patch Domain-Containing ProteinG Patch Domain-Containing Protein 6Zinc Finger Ccch Domain-Containing Protein 9Zinc Finger And G Patch Domain-Containing Protein |
| Cellular Localisation | NucleusIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type With G Patch Domain-Containing Protein antibodyAnti-G Patch Domain-Containing Protein 6 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 9 antibodyAnti-Zinc Finger And G Patch Domain-Containing Protein antibodyAnti-ZGPAT antibodyAnti-GPATC6 antibodyAnti-GPATCH6 antibodyAnti-KIAA1847 antibodyAnti-ZC3H9 antibodyAnti-ZC3HDC9 antibodyAnti-ZIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
