| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZFPM2 (982-1151) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZFPM2 |
| Gene ID: |
23414 |
| Uniprot ID: |
FOG2_HUMAN |
| Immunogen Region: |
982-1151 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 982-1151 of human ZFPM2 (NP_036214.2). |
| Immunogen Sequence: |
SPYYGIKPSDYISGSLVIHN TDIEQSRNAENESPKGQASS NGCAALKKDSLPLLPKNRGM VIVNGGLKQDERPAANPQQE NISQNPQHEDDHKSPSWISE NPLAANENVSPGIPSAEEQL SSIAKGVNGSSQAPTSGKYC RLCDIQFNNLSNFITHKKFY CSSHAAEHVK |
| Tissue Specificity | Widely expressed at low level. |
| Post Translational Modifications | Sumoylation reduces transcriptional repression activity. |
| Function | Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. |
| Protein Name | Zinc Finger Protein Zfpm2Friend Of Gata Protein 2Fog-2Friend Of Gata 2Hfog-2Zinc Finger Protein 89bZinc Finger Protein Multitype 2 |
| Database Links | Reactome: R-HSA-9690406Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Zfpm2 antibodyAnti-Friend Of Gata Protein 2 antibodyAnti-Fog-2 antibodyAnti-Friend Of Gata 2 antibodyAnti-Hfog-2 antibodyAnti-Zinc Finger Protein 89b antibodyAnti-Zinc Finger Protein Multitype 2 antibodyAnti-ZFPM2 antibodyAnti-FOG2 antibodyAnti-ZNF89B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
