| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZFPM1 |
| Gene ID: | 161882 |
| Uniprot ID: | FOG1_HUMAN |
| Immunogen Region: | 1-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ZFPM1 (NP_722520.2). |
| Immunogen Sequence: | MSRRKQSNPRQIKRSLGDME AREEVQLVGASHMEQKATAP EAPSPPSADVNSPPPLPPPT SPGGPKELEGQEPEPRPTEE EPGSPWSGPDELEPVVQDGQ RRIRARLSLATGLSWGPFHG SVQTRASSPRQAEPSPALTL LLVDEACWLRTLPQALTEAE ANTEIHRKDDALWCRVTKPV PAGGLLSVLLTAEPHSTPGH PVKKEPAEPTCPAPAHDLQL LPQQAGMASI |
| Tissue Specificity | Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. |
| Function | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. |
| Protein Name | Zinc Finger Protein Zfpm1 Friend Of Gata Protein 1 Fog-1 Friend Of Gata 1 Zinc Finger Protein 89a Zinc Finger Protein Multitype 1 |
| Database Links | Reactome: R-HSA-8936459 Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Zfpm1 antibody Anti-Friend Of Gata Protein 1 antibody Anti-Fog-1 antibody Anti-Friend Of Gata 1 antibody Anti-Zinc Finger Protein 89a antibody Anti-Zinc Finger Protein Multitype 1 antibody Anti-ZFPM1 antibody Anti-FOG1 antibody Anti-ZFN89A antibody |
Information sourced from Uniprot.org