| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-AN1-type zinc finger protein 5 (84-134) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZFAND5 |
| Gene ID: | 7763 |
| Uniprot ID: | ZFAN5_HUMAN |
| Immunogen Region: | 84-134 |
| Specificity: | This antibody detects endogenous levels of human ZFAN5 |
| Immunogen: | Synthesized peptide derived from human ZFAN5 AA range: 84-134 |
| Function | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
| Protein Name | An1-Type Zinc Finger Protein 5Zinc Finger A20 Domain-Containing Protein 2Zinc Finger Protein 216 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-An1-Type Zinc Finger Protein 5 antibodyAnti-Zinc Finger A20 Domain-Containing Protein 2 antibodyAnti-Zinc Finger Protein 216 antibodyAnti-ZFAND5 antibodyAnti-ZA20D2 antibodyAnti-ZNF216 antibody |
Information sourced from Uniprot.org
