| Function | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
| Protein Name | An1-Type Zinc Finger Protein 5Zinc Finger A20 Domain-Containing Protein 2Zinc Finger Protein 216 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-An1-Type Zinc Finger Protein 5 antibodyAnti-Zinc Finger A20 Domain-Containing Protein 2 antibodyAnti-Zinc Finger Protein 216 antibodyAnti-ZFAND5 antibodyAnti-ZA20D2 antibodyAnti-ZNF216 antibody |
Information sourced from Uniprot.org
