| Tissue Specificity | Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. |
| Post Translational Modifications | Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP51, leading to stabilization. |
| Function | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region. |
| Protein Name | Zinc Finger E-Box-Binding Homeobox 1Nil-2-A Zinc Finger ProteinNegative Regulator Of Il2Transcription Factor 8Tcf-8 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger E-Box-Binding Homeobox 1 antibodyAnti-Nil-2-A Zinc Finger Protein antibodyAnti-Negative Regulator Of Il2 antibodyAnti-Transcription Factor 8 antibodyAnti-Tcf-8 antibodyAnti-ZEB1 antibodyAnti-AREB6 antibodyAnti-TCF8 antibody |
Information sourced from Uniprot.org
