| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Zinc Finger E-Box-Binding Homeobox 1 (800-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4545RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZEB1 |
| Gene ID: |
6935 |
| Uniprot ID: |
ZEB1_HUMAN |
| Immunogen Region: |
800-900 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ZEB1 (NP_110378.3). |
| Immunogen Sequence: |
INIAIPTVTAQLPTIVAIAD QNSVPCLRALAANKQTILIP QVAYTYSTTVSPAVQEPPLK VIQPNGNQDERQDTSSEGVS NVEDQNDSDSTPPKKKMRKT E |
| Tissue Specificity | Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. |
| Function | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region. |
| Protein Name | Zinc Finger E-Box-Binding Homeobox 1Nil-2-A Zinc Finger ProteinNegative Regulator Of Il2Transcription Factor 8Tcf-8 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger E-Box-Binding Homeobox 1 antibodyAnti-Nil-2-A Zinc Finger Protein antibodyAnti-Negative Regulator Of Il2 antibodyAnti-Transcription Factor 8 antibodyAnti-Tcf-8 antibodyAnti-ZEB1 antibodyAnti-AREB6 antibodyAnti-TCF8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
