| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD. |
| Protein Name | Palmitoyltransferase Zdhhc9Zinc Finger Dhhc Domain-Containing Protein 9Dhhc-9Dhhc9 |
| Database Links | Reactome: R-MMU-9648002 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc9 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 9 antibodyAnti-Dhhc-9 antibodyAnti-Dhhc9 antibodyAnti-Zdhhc9 antibody |
Information sourced from Uniprot.org
