| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Palmitoyltransferase ZDHHC21 (177-227 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC21 |
| Gene ID: |
340481 |
| Uniprot ID: |
ZDH21_HUMAN |
| Immunogen Region: |
177-227 aa |
| Specificity: |
This antibody detects endogenous levels of ZDH21 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human ZDH21 at the amino acid range 177-227 |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK. |
| Protein Name | Palmitoyltransferase Zdhhc21Dhhc Domain-Containing Cysteine-Rich Protein 21Dhhc-21Zinc Finger Dhhc Domain-Containing Protein 21 |
| Database Links | Reactome: R-HSA-203615Reactome: R-HSA-9009391 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinGolgi ApparatusCis-Golgi Network MembraneCell Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc21 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 21 antibodyAnti-Dhhc-21 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 21 antibodyAnti-ZDHHC21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
