Anti-ZDHHC15 antibody (231-331) (STJ11105341)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Palmitoyltransferase Zdhhc15 (231-331) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC15 |
| Gene ID | 158866 |
| Uniprot ID | ZDH15_HUMAN |
| Immunogen Region | 231-331 |
| Immunogen Sequence | FGYHCWLVSRNKTTLEAFCT PVFTSGPEKNGFNLGFIKNI QQVFGDKKKFWLIPIGSSPG DGHSFPMRSMNESQNPLLAN EETWEDNEDDNQDYPEGSSS LAVETET |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 231-331 of human ZDHHC15 (NP_659406.1). |
Additional Info
| Tissue Specificity | Expressed in placenta, liver, lung, kidney, heart and brain. |
| Post Translational Modifications | Autopalmitoylated (in vitro). |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex. Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins. In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis. Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon. Could also catalyze the palmitoylation of GAP43. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate FYN as shown in vitro. May palmitoylate CALHM3 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. |
| Protein Name | Palmitoyltransferase Zdhhc15Acyltransferase Zdhhc15Zinc Finger Dhhc Domain-Containing Protein 15Dhhc-15 |
| Database Links | |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinPostsynaptic Density |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc15 antibodyAnti-Acyltransferase Zdhhc15 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 15 antibodyAnti-Dhhc-15 antibodyAnti-ZDHHC15 antibodyAnti-UNQ1969 antibodyAnti-PRO4501 antibody |
Information sourced from Uniprot.org