Anti-ZDHHC1 antibody (81-131 aa) (STJ198039)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZDHC1 at the amino acid range 81-131
General Information
| Short Description | Rabbit polyclonal anti-Palmitoyltransferase ZDHHC1 (81-131 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC1 |
| Gene ID | 29800 |
| Uniprot ID | ZDHC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZDHC1 at the amino acid range 81-131 |
| Immunogen Region | 81-131 aa |
| Specificity | This antibody detects endogenous levels of human ZDHC1 |
Additional Info
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3. Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation. Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7. Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response. Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components. |
| Protein Name | Palmitoyltransferase Zdhhc1Dhhc Domain-Containing Cysteine-Rich Protein 1Zinc Finger Dhhc Domain-Containing Protein 1Dhhc-1Zinc Finger Protein 377 |
| Database Links | |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc1 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 1 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 1 antibodyAnti-Dhhc-1 antibodyAnti-Zinc Finger Protein 377 antibodyAnti-ZDHHC1 antibodyAnti-C16orf1 antibodyAnti-ZNF377 antibody |
Information sourced from Uniprot.org