| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as NCDN and NLRP3. Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation. Acts as an activator of the NLRP3 inflammasome by mediating palmitoylation of 'Cys-130' and 'Cys-958' of NLRP3, thereby promoting NLRP3 phosphorylation and activation by NEK7. Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response. Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components. |
| Protein Name | Palmitoyltransferase Zdhhc1Dhhc Domain-Containing Cysteine-Rich Protein 1Zinc Finger Dhhc Domain-Containing Protein 1Dhhc-1Zinc Finger Protein 377 |
| Database Links | |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc1 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 1 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 1 antibodyAnti-Dhhc-1 antibodyAnti-Zinc Finger Protein 377 antibodyAnti-ZDHHC1 antibodyAnti-C16orf1 antibodyAnti-ZNF377 antibody |
Information sourced from Uniprot.org
