| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc finger and BTB domain-containing protein 49 (31-81 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZBTB49 |
| Gene ID: | 166793 |
| Uniprot ID: | ZBT49_HUMAN |
| Immunogen Region: | 31-81 aa |
| Specificity: | This antibody detects endogenous levels of ZBT49 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human ZBT49 at the amino acid range 31-81 |
| Function | Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. Isoform 1: Binds CDKN1A promoter and activates its transcription.this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 49Zinc Finger Protein 509 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusPredominantly Located In The NucleusIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 49 antibodyAnti-Zinc Finger Protein 509 antibodyAnti-ZBTB49 antibodyAnti-ZNF509 antibody |
Information sourced from Uniprot.org
