Anti-ZBTB17 antibody (121-360) (STJ117000)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZBTB17 (121-360) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZBTB17 |
| Gene ID | 7709 |
| Uniprot ID | ZBT17_HUMAN |
| Immunogen Region | 121-360 |
| Immunogen Sequence | PGGNAEALATEGGDKRAKEE KVATSTLSRLEQAGRSTPIG PSRDLKEERGGQAQSAASGA EQTEKADAPREPPPVELKPD PTSGMAAAEAEAALSESSEQ EMEVEPARKGEEEQKEQEEQ EEEGAGPAEVKEEGSQLENG EAPEENENEESAGTDSGQEL GSEARGLRSGTYGDRTESKA YGSVIHKCEDCGKEFTHTGN FKRHIRIHTGEKPFSCRECS KAFSDPAACKAHEKTHSPL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 121-360 of human ZBTB17 (NP_003434.2). |
Additional Info
| Tissue Specificity | Expressed in germinal center B-cells. |
| Post Translational Modifications | Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner. |
| Function | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription.this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 17Myc-Interacting Zinc Finger Protein 1Miz-1Zinc Finger Protein 151Zinc Finger Protein 60 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 17 antibodyAnti-Myc-Interacting Zinc Finger Protein 1 antibodyAnti-Miz-1 antibodyAnti-Zinc Finger Protein 151 antibodyAnti-Zinc Finger Protein 60 antibodyAnti-ZBTB17 antibodyAnti-MIZ1 antibodyAnti-ZNF151 antibodyAnti-ZNF60 antibody |
Information sourced from Uniprot.org