| Short Description : | Rabbit monoclonal Zinc Finger And Btb Domain-Containing Protein 16 (199-300) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4224RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:2000-1:10000IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZBTB16 |
| Gene ID: | 7704 |
| Uniprot ID: | ZBT16_HUMAN |
| Immunogen Region: | 199-300 |
| Immunogen Sequence: | TKAAVDSLMTIGQSLLQGTL QPPAGPEEPTLAGGGRHPGV AEVKTEMMQVDEVPSQDSPG AAESSISGGMGDKVEERGKE GPGTPTRSSVITSARELHYG RE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-300 of human PLZF (NP_005997.2). |
| Tissue Specificity | Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung. |
| Function | Acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 16Promyelocytic Leukemia Zinc Finger ProteinZinc Finger Protein 145Zinc Finger Protein Plzf |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNuclear Body |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 16 antibodyAnti-Promyelocytic Leukemia Zinc Finger Protein antibodyAnti-Zinc Finger Protein 145 antibodyAnti-Zinc Finger Protein Plzf antibodyAnti-ZBTB16 antibodyAnti-PLZF antibodyAnti-ZNF145 antibody |
Information sourced from Uniprot.org
