Anti-ZBTB1 antibody (STJA0004885)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human ZBTB1
General Information
| Short Description | Rabbit polyclonal anti-Zinc Finger And Btb Domain-Containing Protein 1 for use in WB, IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | WB 1:1000-1:5000, IHC 1:25-1:100 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ZBTB1 |
| Gene ID | 22890 |
| Uniprot ID | ZBTB1_HUMAN |
| Immunogen | Synthetic peptide of human ZBTB1 |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization. |
| Function | Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmLocalized In Dot-Like Structures In The NucleusColocalized With Smrt In Nuclear BodiesThe Sumoylated Form Is Preferentially Located In The Nucleoplasm Outside The Nuclear Bodies |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 1 antibodyAnti-ZBTB1 antibodyAnti-KIAA0997 antibody |
Information sourced from Uniprot.org