| Host: | Rabbit |
| Applications: | WB/IHC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc Finger And Btb Domain-Containing Protein 1 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 0.6 mg/mL |
| Dilution Range: | WB 1:1000-1:5000, IHC 1:25-1:100 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | ZBTB1 |
| Gene ID: | 22890 |
| Uniprot ID: | ZBTB1_HUMAN |
| Immunogen: | Synthetic peptide of human ZBTB1 |
| Post Translational Modifications | Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization. |
| Function | Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 1 |
| Cellular Localisation | Nucleus Nucleoplasm Localized In Dot-Like Structures In The Nucleus Colocalized With Smrt In Nuclear Bodies The Sumoylated Form Is Preferentially Located In The Nucleoplasm Outside The Nuclear Bodies |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 1 antibody Anti-ZBTB1 antibody Anti-KIAA0997 antibody |
Information sourced from Uniprot.org