| Post Translational Modifications | Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization. |
| Function | Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasmLocalized In Dot-Like Structures In The NucleusColocalized With Smrt In Nuclear BodiesThe Sumoylated Form Is Preferentially Located In The Nucleoplasm Outside The Nuclear Bodies |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 1 antibodyAnti-ZBTB1 antibodyAnti-KIAA0997 antibody |
Information sourced from Uniprot.org
