| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-YWHAQ (49-149) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YWHAQ |
| Gene ID: |
10971 |
| Uniprot ID: |
1433T_HUMAN |
| Immunogen Region: |
49-149 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 49-149 of human 14-3-3 Theta (NP_006817.1). |
| Immunogen Sequence: |
KNVVGGRRSAWRVISSIEQK TDTSDKKLQLIKDYREKVES ELRSICTTVLELLDKYLIAN ATNPESKVFYLKMKGDYFRY LAEVACGDDRKQTIDNSQGA Y |
| Tissue Specificity | Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. |
| Post Translational Modifications | Ser-232 is probably phosphorylated by CK1. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. |
| Protein Name | 14-3-3 Protein Theta14-3-3 Protein T-Cell14-3-3 Protein TauProtein Hs1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-9614399Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | CytoplasmIn NeuronsAxonally Transported To The Nerve Terminals |
| Alternative Antibody Names | Anti-14-3-3 Protein Theta antibodyAnti-14-3-3 Protein T-Cell antibodyAnti-14-3-3 Protein Tau antibodyAnti-Protein Hs1 antibodyAnti-YWHAQ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
