| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-YTHDC2 (1131-1430) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YTHDC2 |
| Gene ID: |
64848 |
| Uniprot ID: |
YTDC2_HUMAN |
| Immunogen Region: |
1131-1430 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1131-1430 of human YTHDC2 (NP_073739.3). |
| Immunogen Sequence: |
HSLFLRRMRAPSKPWSQVDE ATIRAIIAVLSTEEQSAGLQ QPSGIGQRPRPMSSEELPLA SSWRSNNSRKSSADTEFSDE CTTAERVLMKSPSPALHPPQ KYKDRGILHPKRGTEDRSDQ SSLKSTDSSSYPSPCASPSP PSSGKGSKSPSPRPNMPVRY FIMKSSNLRNLEISQQKGIW STTPSNERKLNRAFWESSIV YLVFSVQGSGHFQGFSRMSS EIGREKSQDWGSAGLGGVF |
| Tissue Specificity | Expressed in testis. Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis. |
| Function | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. |
| Protein Name | 3'-5' Rna Helicase Ythdc2Yth Domain-Containing Protein 2Hythdc2 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-3'-5' Rna Helicase Ythdc2 antibodyAnti-Yth Domain-Containing Protein 2 antibodyAnti-Hythdc2 antibodyAnti-YTHDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
