| Function | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. |
| Protein Name | Ubiquitin Thioesterase Otu1Duba-8Hiv-1-Induced Protease 7Hin-7Hshin7Otu Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Ubiquitin Thioesterase Otu1 antibodyAnti-Duba-8 antibodyAnti-Hiv-1-Induced Protease 7 antibodyAnti-Hin-7 antibodyAnti-Hshin7 antibodyAnti-Otu Domain-Containing Protein 2 antibodyAnti-YOD1 antibodyAnti-DUBA8 antibodyAnti-HIN7 antibodyAnti-OTUD2 antibodyAnti-PRO0907 antibody |
Information sourced from Uniprot.org
