Anti-YME1L1 antibody (720-773) {FITC} (STJ503569)

SKU:
STJ503569-100

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-YME1L1 (720-773) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: YME1L1
Gene ID: 10730
Uniprot ID: YMEL1_HUMAN
Immunogen Region: 720-773
Immunogen: Synthetic peptide taken within amino acid region 720-773 on human ATP-dependent metalloprotease YME1L1 protein.
Tissue Specificity High expression in cardiac and skeletal muscle mitochondria.
Post Translational Modifications Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form.
Function ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).
Protein Name Atp-Dependent Zinc Metalloprotease Yme1l1
Atp-Dependent Metalloprotease Ftsh1
Meg-4
Presenilin-Associated Metalloprotease
Pamp
Yme1-Like Protein 1
Database Links Reactome: R-HSA-8949664
Cellular Localisation Mitochondrion Inner Membrane
Mitochondrion
Alternative Antibody Names Anti-Atp-Dependent Zinc Metalloprotease Yme1l1 antibody
Anti-Atp-Dependent Metalloprotease Ftsh1 antibody
Anti-Meg-4 antibody
Anti-Presenilin-Associated Metalloprotease antibody
Anti-Pamp antibody
Anti-Yme1-Like Protein 1 antibody
Anti-YME1L1 antibody
Anti-FTSH1 antibody
Anti-YME1L antibody
Anti-UNQ1868 antibody
Anti-PRO4304 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance