| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-YME1L1 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YME1L1 |
| Gene ID: |
10730 |
| Uniprot ID: |
YMEL1_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human YME1L1 (NP_055078.1). |
| Immunogen Sequence: |
MFSLSSTVQPQVTVPLSHLI NAFHTPKNTSVSLSGVSVSQ NQHRDVVPEHEAPSSEPSLN LRDLGLSELKIGQIDQLVEN LLPGFCKGKNISSHWHTSHV SAQSFFENKYGNLDIFSTLR SSCLYRHHSRALQSICSDLQ YWPVFIQSRGFKTLKSRTRR LQSTSERLAETQNIAPSFVK GFLLRDRGSDVESLDKLMKT KNIPEAHQDAFKTGFAEGFL KAQALTQKTNDSLRRTRLI |
| Tissue Specificity | High expression in cardiac and skeletal muscle mitochondria. |
| Post Translational Modifications | Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. |
| Function | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). |
| Protein Name | Atp-Dependent Zinc Metalloprotease Yme1l1Atp-Dependent Metalloprotease Ftsh1Meg-4Presenilin-Associated MetalloproteasePampYme1-Like Protein 1 |
| Database Links | Reactome: R-HSA-8949664 |
| Cellular Localisation | Mitochondrion Inner MembraneMitochondrion |
| Alternative Antibody Names | Anti-Atp-Dependent Zinc Metalloprotease Yme1l1 antibodyAnti-Atp-Dependent Metalloprotease Ftsh1 antibodyAnti-Meg-4 antibodyAnti-Presenilin-Associated Metalloprotease antibodyAnti-Pamp antibodyAnti-Yme1-Like Protein 1 antibodyAnti-YME1L1 antibodyAnti-FTSH1 antibodyAnti-YME1L antibodyAnti-UNQ1868 antibodyAnti-PRO4304 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
