| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
YME1L1 |
| Gene ID: |
10730 |
| Uniprot ID: |
YMEL1_HUMAN |
| Immunogen Region: |
1-240 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human YME1L1 (NP_055078.1). |
| Immunogen Sequence: |
MFSLSSTVQPQVTVPLSHLI NAFHTPKNTSVSLSGVSVSQ NQHRDVVPEHEAPSSEPSLN LRDLGLSELKIGQIDQLVEN LLPGFCKGKNISSHWHTSHV SAQSFFENKYGNLDIFSTLR SSCLYRHHSRALQSICSDLQ YWPVFIQSRGFKTLKSRTRR LQSTSERLAETQNIAPSFVK GFLLRDRGSDVESLDKLMKT KNIPEAHQDAFKTGFAEGFL KAQALTQKTNDSLRRTRLI |
| Tissue Specificity | High expression in cardiac and skeletal muscle mitochondria. |
| Post Translational Modifications | Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. Degraded in an OMA1-dependent manner in response to oxidative stress. |
| Function | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Involved in the mitochondrial adaptation in response to various signals, such as stress or developmental cues, by mediating degradation of mitochondrial proteins to rewire the mitochondrial proteome. Catalyzes degradation of mitochondrial proteins, such as translocases, lipid transfer proteins and metabolic enzymes in response to nutrient starvation in order to limit mitochondrial biogenesis: mechanistically, YME1L is activated by decreased phosphatidylethanolamine levels caused by LPIN1 activity in response to mTORC1 inhibition. Acts as a regulator of adult neural stem cell self-renewal by promoting mitochondrial proteome rewiring, preserving neural stem and progenitor cells self-renewal. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Mediates degradation of TIMM17A downstream of the integrated stress response (ISR). Catalyzes degradation of MICU1 when MICU1 is not assembled via an interchain disulfide. |
| Protein Name | Atp-Dependent Zinc Metalloprotease Yme1l1Atp-Dependent Metalloprotease Ftsh1Meg-4Presenilin-Associated MetalloproteasePampYme1-Like Protein 1 |
| Database Links | Reactome: R-HSA-8949664Reactome: R-HSA-9837999Reactome: R-HSA-9840373 |
| Cellular Localisation | Mitochondrion Inner MembraneMitochondrion |
| Alternative Antibody Names | Anti-Atp-Dependent Zinc Metalloprotease Yme1l1 antibodyAnti-Atp-Dependent Metalloprotease Ftsh1 antibodyAnti-Meg-4 antibodyAnti-Presenilin-Associated Metalloprotease antibodyAnti-Pamp antibodyAnti-Yme1-Like Protein 1 antibodyAnti-YME1L1 antibodyAnti-FTSH1 antibodyAnti-YME1L antibodyAnti-UNQ1868 antibodyAnti-PRO4304 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
